Article
Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.
Molecular cell - 5 Jan 2017
Billon Pierre, Li Jian, Lambert Jean-Philippe, Chen Yizhang, Tremblay Véronique, Brunzelle Joseph S, Gingras Anne-Claude, Verreault Alain, Sugiyama Tomohiko, Couture Jean-Francois, Côté Jacques
Abstract excerpt
During DNA replication, proliferating cell nuclear antigen (PCNA) adopts a ring-shaped structure to promote processive DNA synthesis, acting as a sliding clamp for polymerases. Known posttranslational modifications function at the outer surface of the PCNA ring to favor DNA damage bypass. Here, we demonstrate that acetylation of lysine residues at the inner surface of PCNA is induced by DNA lesions. We show that...
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