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Article

Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress.

Journal of biomechanics - 4 Jan 2017

McCormick Margaret E, Manduchi Elisabetta, Witschey Walter R T, Gorman Robert C, Gorman Joseph H, Jiang Yi-Zhou, Stoeckert Christian J, Barker Alex J, Yoon Samuel, Markl Michael, Davies Peter F

Abstract excerpt

Despite substantial evidence for the central role of hemodynamic shear stress in the functional integrity of vascular endothelial cells, hemodynamic and molecular regulation of the endocardial endothelium lining the heart chambers remains understudied. We propose that regional differences in intracardiac hemodynamics influence differential endocardial gene expression leading to phenotypic heterogeneity of this...

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Identifiers

PMID: 27916240
DOI: 10.1016/j.jbiomech.2016.11.018
PMCID: PMC5513694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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