Article
CRISPR knockout rat cytochrome P450 3A1/2 model for advancing drug metabolism and pharmacokinetics research.
Scientific reports - 20 Feb 2017
Lu Jian, Shao Yanjiao, Qin Xuan, Liu Daozhi, Chen Ang, Li Dali, Liu Mingyao, Wang Xin
Abstract excerpt
Cytochrome P450 (CYP) 3A accounts for nearly 30% of the total CYP enzymes in the human liver and participates in the metabolism of over 50% of clinical drugs. Moreover, CYP3A plays an important role in chemical metabolism, toxicity, and carcinogenicity. New animal models are needed to investigate CYP3A functions, especially for drug metabolism. In this report, Cyp3a1/2 double knockout (KO) rats were generated by...
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