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Article

CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.

Nature communications - 27 Jul 2016

Jacoby Elad, Nguyen Sang M, Fountaine Thomas J, Welp Kathryn, Gryder Berkley, Qin Haiying, Yang Yinmeng, Chien Christopher D, Seif Alix E, Lei Haiyan, Song Young K, Khan Javed, Lee Daniel W, Mackall Crystal L, Gardner Rebecca A, Jensen Michael C, Shern Jack F, Fry Terry J

Abstract excerpt

Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustained pressure against CD19 that may drive unique mechanisms of resistance. Pre-B ALL originates from a committed pre-B cell or an earlier progenitor, with potential to...

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Identifiers

PMID: 27460500
DOI: 10.1038/ncomms12320
PMCID: PMC4974466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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