Article
Phenotypic and genotypic infidelity in B-lineage neoplasms, including transdifferentiation following targeted therapy: Report from the 2021 SH/EAHP Workshop.
American journal of clinical pathology - 1 Jun 2023
Goodlad John R, Xiao Wenbin, Amador Catalina, Cook James R, Happ Lanie, Thakkar Devang, Dave Sandeep, Dogan Ahmet, Duffield Amy, Nejati Reza, Ott German, Wasik Mariusz, Czader Magdalena
Abstract excerpt
OBJECTIVES: Session 2 of the 2021 Society for Hematopathology and European Association for Haematopathology Workshop collected examples of lineage infidelity and transdifferentiation in B-lineage neoplasms, including after targeted therapy. METHODS: Twenty cases were submitted. Whole-exome sequencing and genome-wide RNA expression analysis were available on a limited subsample. RESULTS: A diagnosis of B-cell...
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