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Genetics and pathologic landscape of lineage switch of acute leukemia during therapy

25 Jan 2024

Abstract excerpt

Lineage switch in leukemia, characterized by a complete cell-fate conversion from one lineage to another, is associated with a dismal prognosis. The era of immunotherapy has witnessed a notable increase in its incidence, approaching 8% of B-ALL following anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy [ 1 ]. This significant challenge underscores the pressing need for a deeper understanding of lineage...

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PMID: 38272888
DOI: 10.1038/s41408-024-00983-2

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