Article
Polymorphisms of genes involved in the hypoxia signaling pathway and the development of abdominal aortic aneurysms or large-artery atherosclerosis.
Journal of vascular surgery - 1 May 2015
Strauss Ewa, Waliszewski Krzysztof, Oszkinis Grzegorz, Staniszewski Ryszard
Abstract excerpt
BACKGROUND: The pathogenesis of aortic diseases, both aneurysmal and occlusive, is associated with the occurrence of local ischemic/hypoxic conditions, but the genetic factors that differentiate the predisposition to specific types of aortic diseases are largely unknown. In this study, the functional variants in genes involved in the hypoxia signaling pathway, hypoxia-inducible factor-1α (HIF1A) 1772C>T, 1790G>A,...
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