Article
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
Nature genetics - 1 Oct 2008
To Minh D, Wong Christine E, Karnezis Anthony N, Del Rosario Reyno, Di Lauro Roberto, Balmain Allan
Abstract excerpt
Kras is the most frequently mutated ras family member in lung carcinomas, whereas Hras mutations are common in tumors from stratified epithelia such as the skin. Using a Hras knock-in mouse model, we demonstrate that specificity for Kras mutations in lung and Hras mutations in skin tumors is determined by local regulatory elements in the target ras genes. Although the Kras 4A isoform is dispensable for mouse...
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