Article
Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene-environment interaction for the risk of dementia and Alzheimer's disease dementia.
Psychological medicine - 1 Apr 2014
Luck T, Riedel-Heller S G, Luppa M, Wiese B, Köhler M, Jessen F, Bickel H, Weyerer S, Pentzek M, König H-H, Prokein J, Ernst A, Wagner M, Mösch E, Werle J, Fuchs A, Brettschneider C, Scherer M, Maier W
Abstract excerpt
BACKGROUND: As physical activity may modify the effect of the apolipoprotein E (APOE) ε4 allele on the risk of dementia and Alzheimer's disease (AD) dementia, we tested for such a gene-environment interaction in a sample of general practice patients aged ⩾75 years. METHOD: Data were derived from follow-up waves I-IV of the longitudinal German study on Ageing, Cognition and Dementia in Primary Care Patients...
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