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Article

SAHA and/or MG132 reverse the aggressive phenotypes of glioma cells: An in vitro and vivo study.

Oncotarget - 10 Jan 2017

Yang Xue-Feng, Zhao Zhi-Juan, Liu Jia-Jie, Yang Xiang-Hong, Gao Yang, Zhao Shuang, Shi Shuai, Huang Ke-Qiang, Zheng Hua-Chuan

Abstract excerpt

To elucidate the anti-tumor effects and molecular mechanisms of SAHA (a histone deacetylase inhibitor) and MG132 (a proteasome inhibitor) on the aggressive phenotypes of glioma cells, we treated U87 and U251 cells with SAHA or/and MG132, and detected phenotypes' assays with phenotype-related molecules examined. It was found that SAHA or/and MG132 treatment suppressed proliferation in both concentration- and...

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Identifiers

PMID: 27911270
DOI: 10.18632/oncotarget.13680
PMCID: PMC5356872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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