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Suberoylanilide hydroxamic acid represses glioma stem-like cells

18 Nov 2016

Abstract excerpt

BACKGROUND: Glioma stem-like cells (GSCs) are proposed to be responsible for high resistance in glioblastoma multiforme (GBM) treatment. In order to find new strategies aimed at reducing GSC stemness and improving GBM patient survival, we investigated the effects and mechanism of a histone deacetylases (HDACs) inhibitor, suberoylanilide hydroxamic acid (SAHA), since HDAC activity has been linked to cancer...

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Share to Epigenetics and DNA Methylation
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PMID: 27863490
DOI: 10.1186/s12929-016-0296-6

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