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Article

HDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells.

Cancer letters - 1 Jul 2017

Marampon Francesco, Megiorni Francesca, Camero Simona, Crescioli Clara, McDowell Heather P, Sferra Roberta, Vetuschi Antonella, Pompili Simona, Ventura Luca, De Felice Francesca, Tombolini Vincenzo, Dominici Carlo, Maggio Roberto, Festuccia Claudio, Gravina Giovanni Luca

Abstract excerpt

The role of histone deacetylase (HDAC) 4 and 6 in glioblastoma (GBM) radioresistance was investigated. We found that tumor samples from 31 GBM patients, who underwent temozolomide and radiotherapy combined treatment, showed HDAC4 and HDAC6 expression in 93.5% and 96.7% of cases, respectively. Retrospective clinical data analysis demonstrated that high-intensity HDAC4 and/or HDAC6 immunostaining was predictive of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Dose-Response Relationship, Radiation

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Source

Identifiers

PMID: 28342984
DOI: 10.1016/j.canlet.2017.03.028

Genes

HDAC4
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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