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The novel histone deacetylase inhibitor pracinostat suppresses the malignant phenotype in human glioma.

Molecular biology reports - 1 Aug 2022

Chen Mantao, Zhang Luyuan, Zhan Renya, Zheng Xiujue

Abstract excerpt

INTRODUCTION: Glioma is the most common malignant brain tumor in adults. The effects of conventional treatment regimens are still limited to prolonging the survival of patients. Histone deacetylases (HDACs) are potential targets for tumor treatment. Pracinostat is a new type of HDAC inhibitor (HDACi) that has a significant antitumor effect on a variety of tumors. Thus, we aim to investigate the role of...

Topics

Adult
Apoptosis
Benzimidazoles
Cell Line, Tumor
Cell Movement
Cell Proliferation
Glioma
Histone Deacetylase Inhibitors
Humans
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Phosphatidylinositol 3-Kinases

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PMID: 35622308
DOI: 10.1007/s11033-022-07559-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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