Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.

PLoS genetics - 1 Dec 2016

Cornils Astrid, Maurya Ashish K, Tereshko Lauren, Kennedy Julie, Brear Andrea G, Prahlad Veena, Blacque Oliver E, Sengupta Piali

Abstract excerpt

The majority of cilia are formed and maintained by the highly conserved process of intraflagellar transport (IFT). Mutations in IFT genes lead to ciliary structural defects and systemic disorders termed ciliopathies. Here we show that the severely truncated sensory cilia of hypomorphic IFT mutants in C. elegans transiently elongate during a discrete period of adult aging leading to markedly improved sensory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Microtubules

Share to Molecular Chaperones

Share to Mutation

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27906968
DOI: 10.1371/journal.pgen.1006325
PMCID: PMC5131903

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.PMID 27906968Read ↗

Complement Factor H and its <i>C. elegans</i> homolog regulate IFT52/OSM-6 and CNG channel localization in sensory neuronsSemantic proximity Read ↗

Regulation of aging and age-related disease by DAF-16 and heat-shock factor.Semantic proximity Read ↗

Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans.Semantic proximity Read ↗

Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.Semantic proximity Read ↗

<i>Caenorhabditis elegans </i><scp>HSF</scp>‐1 is an essential nuclear protein that forms stress granule‐like structures following heat shockSemantic proximity Read ↗

HSF-1–mediated cytoskeletal integrity determines thermotolerance and life spanSemantic proximity Read ↗

Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans.Semantic proximity Read ↗

Functional genomics of intraflagellar transport-associated proteins in C. elegans.Semantic proximity Read ↗

The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport.Semantic proximity Read ↗

Multiple regulators constrain the abundance of Caenorhabditis elegans DLK-1 in ciliated sensory neurons.Semantic proximity Read ↗

In vivo properties of the disaggregase function of J‐proteins and Hsc70 in Caenorhabditis elegans stress and agingSemantic proximity Read ↗

Age‐dependent heat shock hormesis to HSF ‐1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.