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Article

Structural and Functional Recovery of Sensory Cilia in C. elegans IFT Mutants upon Aging.

PLoS genetics - 1 Dec 2016

Cornils Astrid, Maurya Ashish K, Tereshko Lauren, Kennedy Julie, Brear Andrea G, Prahlad Veena, Blacque Oliver E, Sengupta Piali

Abstract excerpt

The majority of cilia are formed and maintained by the highly conserved process of intraflagellar transport (IFT). Mutations in IFT genes lead to ciliary structural defects and systemic disorders termed ciliopathies. Here we show that the severely truncated sensory cilia of hypomorphic IFT mutants in C. elegans transiently elongate during a discrete period of adult aging leading to markedly improved sensory...

Topics

Aging
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cilia
Ciliopathies
Forkhead Transcription Factors
HSP90 Heat-Shock Proteins
Humans
Microtubules
Molecular Chaperones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Sensory Receptor Cells

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27906968
DOI: 10.1371/journal.pgen.1006325
PMCID: PMC5131903

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27906968-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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