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Article

Whole genome amplification of plasma-circulating DNA enables expanded screening for allelic imbalance in plasma.

The Journal of molecular diagnostics : JMD - 1 Feb 2006

Li Jin, Harris Lyndsay, Mamon Harvey, Kulke Matthew H, Liu Wei-Hua, Zhu Penny, Mike Makrigiorgos G

Abstract excerpt

Apoptotic and necrotic tumor cells release DNA into plasma, providing an accessible tumor biomarker. Tumor-released plasma-circulating DNA can be screened for tumor-specific genetic changes, including mutation, methylation, or allelic imbalance. However, technical problems relating to the quantity and quality of DNA collected from plasma hinder downstream genetic screening and reduce biomarker detection...

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Share to Allelic Imbalance
Share to Chromatography, High Pressure Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16436631
DOI: 10.2353/jmoldx.2006.050074
PMCID: PMC1867563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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