Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of hepatitis B virus replication by activation of the cGAS-STING pathway

1 Nov 2016

Abstract excerpt

Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses cytosolic DNA and catalyses synthesis of the second messenger cGAMP, which activates the downstream signalling adaptor protein STING, leading to the expression of type I interferons. Hepatitis B virus (HBV) is a small DNA virus, and the cGAS-STING pathway may inhibit HBV RNA synthesis and viral assembly in cell culture, but the exact roles of the cGAS pathway in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to interferon and immune responses
Share to Viral Infections and Outbreaks Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27902332
DOI: 10.1099/jgv.0.000647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of hepatitis B virus replication by activation of the cGAS-STING pathwayPMID 27902332Read ↗

Activation of cGAS-STING signaling pathway during HCV infectionSemantic proximity Read ↗

Significance of the cGAS-STING Pathway in Health and DiseaseSemantic proximity Read ↗

The regulation of cGAS-STING signaling by RNA virus-derived componentsSemantic proximity Read ↗

Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory ResponseSemantic proximity Read ↗

Function and regulation of cGAS-STING signaling in infectious diseasesSemantic proximity Read ↗

Advances in cGAS-STING Signaling Pathway and DiseasesSemantic proximity Read ↗

The triggers of the cGAS-STING pathway and the connection with inflammatory and autoimmune diseasesSemantic proximity Read ↗

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseasesSemantic proximity Read ↗

A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse FunctionsSemantic proximity Read ↗

Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and ImmunotherapySemantic proximity Read ↗

The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagySemantic proximity Read ↗

Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.