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Article

Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses.

Journal of virology - 1 Jan 2016

Yi Guanghui, Wen Yahong, Shu Chang, Han Qingxia, Konan Kouacou V, Li Pingwei, Kao C Cheng

Abstract excerpt

UNLABELLED: The cyclic dinucleotide 2',3'-cGAMP can bind the adaptor protein STING (stimulator of interferon [IFN] genes) to activate the production of type I IFNs and proinflammatory cytokines. We found that cGAMP added to the culture medium could suppress the replication of the hepatitis C virus (HCV) genotype 1b strain Con1 subgenomic replicon in human hepatoma cells. Knockdown of STING expression diminished...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26468527
DOI: 10.1128/JVI.01720-15
PMCID: PMC4702547

Genes

MAVS
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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