Article

Recurrent<i>ERBB2</i>alterations are associated with esophageal adenocarcinoma brain metastases

2025-02-26

Abstract excerpt

<h4>Summary</h4> Brain metastases in esophageal adenocarcinoma (EAC) patients are associated with poor prognosis and remain understudied. We performed multi-omics analysis with whole-genome sequencing and single-cell spatial transcriptomics on the brain metastases and matched primary tumors. Our analysis identified ERBB2 as a recurrent oncogene in EAC brain metastases, with 9 out of 10 cases harboring amplificatio...

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Literature Corpus work: 3ea96ff6-4d4b-51e7-be25-19d6da3b539d
DOI: 10.1101/2025.02.19.25322558

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