Article
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment.
Cancer cell - 11 Jan 2021
Wheeler David A, Takebe Naoko, Hinoue Toshinori, Hoadley Katherine A, Cardenas Maria F, Hamilton Alina M, Laird Peter W, Wang Linghua, Johnson Adrienne, Dewal Ninad, Miller Vincent, Piñeyro David, Castro de Moura Manuel, Esteller Manel, Shen Hui, Zenklusen Jean Claude, Tarnuzzer Roy, McShane Lisa M, Tricoli James V, Williams Paul M, Lubensky Irina, O'Sullivan-Coyne Geraldine, Kohn Elise C, Little Richard F, White Jeffrey, Malik Shakun, Harris Lyndsay, Weil Carol, Chen Alice P, Karlovich Chris, Rodgers Brian, Shankar Lalitha, Jacobs Paula, Nolan Tracy, Hu Jianhong, Muzny Donna M, Doddapaneni Harshavardhan, Korchina Viktoriya, Gastier-Foster Julie, Bowen Jay, Leraas Kristen, Edmondson Elijah F, Doroshow James H, Conley Barbara A, Ivy S Percy, Staudt Louis M
Abstract excerpt
A small fraction of cancer patients with advanced disease survive significantly longer than patients with clinically comparable tumors. Molecular mechanisms for exceptional responses to therapy have been identified by genomic analysis of tumor biopsies from individual patients. Here, we analyzed tumor biopsies from an unbiased cohort of 111 exceptional responder patients using multiple platforms to profile...
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