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Article

High-Resolution Profiling of Lung Adenocarcinoma Identifies Expression Subtypes with Specific Biomarkers and Clinically Relevant Vulnerabilities.

Cancer research - 2 Nov 2022

Roh Whijae, Geffen Yifat, Cha Hongui, Miller Mendy, Anand Shankara, Kim Jaegil, Heiman David I, Gainor Justin F, Laird Peter W, Cherniack Andrew D, Ock Chan-Young, Lee Se-Hoon, Getz Gad

Abstract excerpt

Lung adenocarcinoma (LUAD) is one of the most common cancer types and has various treatment options. Better biomarkers to predict therapeutic response are needed to guide choice of treatment modality and to improve precision medicine. Here, we used a consensus hierarchical clustering approach on 509 LUAD cases from The Cancer Genome Atlas to identify five robust LUAD expression subtypes. Genomic and proteomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36040373
DOI: 10.1158/0008-5472.CAN-22-0432
PMCID: PMC9718502

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