BNC2 is a putative tumor suppressor gene in high-grade serous ovarian carcinoma and impacts cell survival after oxidative stress.

doi:10.1038/cddis.2016.278

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Article

BNC2 is a putative tumor suppressor gene in high-grade serous ovarian carcinoma and impacts cell survival after oxidative stress.

Cell death & disease - 22 Sept 2016

Cesaratto Laura, Grisard Eleonora, Coan Michela, Zandonà Luigi, De Mattia Elena, Poletto Elena, Cecchin Erika, Puglisi Fabio, Canzonieri Vincenzo, Mucignat Maria Teresa, Zucchetto Antonella, Stocco Gabriele, Colombatti Alfonso, Nicoloso Milena S, Spizzo Riccardo

Abstract excerpt

Rs3814113 is the single-nucleotide polymorphism (SNP) showing the strongest association with high-grade serous ovarian carcinoma (HGSOC) incidence and is located in an intergenic region about 44 kb downstream of basonuclin 2 (BNC2) gene. Lifetime number of ovulations is associated with increased risk to develop HGSOC, probably because of cell damage of extrauterine Müllerian epithelium by ovulation-induced...

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Identifiers

PMID: 27899818
DOI: 10.1038/cddis.2016.278
PMCID: PMC5059877

Genes

BNC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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