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Article

Nonequivalent gene expression and copy number alterations in high-grade serous ovarian cancers with BRCA1 and BRCA2 mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2013

George Joshy, Alsop Kathryn, Etemadmoghadam Dariush, Hondow Heather, Mikeska Thomas, Dobrovic Alexander, deFazio Anna, Smyth Gordon K, Levine Douglas A, Mitchell Gillian, Bowtell David D

Abstract excerpt

PURPOSE: High-grade serous carcinoma (HGSC) accounts for the majority of epithelial ovarian cancer deaths. Genomic and functional data suggest that approximately half of unselected HGSC have disruption of the BRCA pathway and defects in homologous recombination repair (HRR). Pathway disruption is...

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Source

Identifiers

PMID: 23633455
DOI: 10.1158/1078-0432.CCR-13-0066

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23633455-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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