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Article

Distinct BNC1 variants contribute to premature ovarian insufficiency through different molecular mechanisms.

Gene - 20 May 2026

Zheng Zhi, Chu Chunfang, Zhao Minying, Sun Yujun, Chen Shuya, Li Yuxiao, He Lin, Xin Mingwei, Li Lin

Abstract excerpt

Premature ovarian insufficiency (POI) is a major cause of female infertility, and accumulating evidence indicates that genetic variants contribute to its pathogenesis. To further explore the genetic basis of POI, we performed a whole-exome sequencing among 121 women with POI and identified three rare heterozygous BNC1 gene variants, which include two missense variants, p.(Leu532Pro) and p.(Ser938Asn), and one...

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Source

Identifiers

PMID: 41833801
DOI: 10.1016/j.gene.2026.150104

Genes

BNC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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