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Article

NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer.

Aging - 19 Sept 2023

Wang Wenjing, Liu Ruiqian, Liao Wei, Ji Landie, Mei Jie, Su Dan

Abstract excerpt

The carcinogenic mechanisms by which serous ovarian cancer (OC) occurs remain to be explored. Currently, we have conducted whole-exome sequencing (WES) and targeted deep sequencing to validate new molecular markers, including NOTCH2, that impede the progression of cell malignancy in ovarian cancer (OC). Following NOTCH2 P2113S mutation and NOTCH signaling pathway inhibitor...

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Source

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Identifiers

PMID: 37728427
DOI: 10.18632/aging.205045
PMCID: PMC10564443

Genes

NOTCH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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