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Article

Structure of a Cytoplasmic 11-Subunit RNA Exosome Complex.

Molecular cell - 7 Jul 2016

Kowalinski Eva, Kögel Alexander, Ebert Judith, Reichelt Peter, Stegmann Elisabeth, Habermann Bianca, Conti Elena

Abstract excerpt

The RNA exosome complex associates with nuclear and cytoplasmic cofactors to mediate the decay, surveillance, or processing of a wide variety of transcripts. In the cytoplasm, the conserved core of the exosome (Exo10) functions together with the conserved Ski complex. The interaction of S. cerevisiae Exo10 and Ski is not direct but requires a bridging cofactor, Ski7. Here, we report the 2.65 Å resolution...

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Identifiers

PMID: 27345150
DOI: 10.1016/j.molcel.2016.05.028
PMCID: PMC4942675

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