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Article

BindProfX: Assessing Mutation-Induced Binding Affinity Change by Protein Interface Profiles with Pseudo-Counts.

Journal of molecular biology - 3 Feb 2017

Xiong Peng, Zhang Chengxin, Zheng Wei, Zhang Yang

Abstract excerpt

Understanding how gene-level mutations affect the binding affinity of protein-protein interactions is a key issue of protein engineering. Due to the complexity of the problem, using physical force field to predict the mutation-induced binding free-energy change remains challenging. In this work, we present a renewed approach to calculate the impact of gene mutations on the binding affinity through the...

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Identifiers

PMID: 27899282
DOI: 10.1016/j.jmb.2016.11.022
PMCID: PMC5963940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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