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Article

Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles.

PLoS computational biology - 1 Oct 2015

Brender Jeffrey R, Zhang Yang

Abstract excerpt

The formation of protein-protein complexes is essential for proteins to perform their physiological functions in the cell. Mutations that prevent the proper formation of the correct complexes can have serious consequences for the associated cellular processes. Since experimental determination of protein-protein binding affinity remains difficult when performed on a large scale, computational methods for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26506533
DOI: 10.1371/journal.pcbi.1004494
PMCID: PMC4624718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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