Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes.

Abstract excerpt

Additivity in binding affinity of protein-protein complexes refers to the change in free energy of binding (ΔΔGbind ) for double (or multiple) mutations which is approximately equal to the sum of their corresponding single mutation ΔΔGbind values. In this study, we have explored the additivity effect of double mutants, which shows a linear relationship between the binding affinity of double and sum of single...

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