Article
IDENTIFY CANCER DRIVER GENES THROUGH SHARED MENDELIAN DISEASE PATHOGENIC VARIANTS AND CANCER SOMATIC MUTATIONS.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2017
Ma Meng, Wang Changchang, Glicksberg Benjamin S, Schadt Eric E, Li Shuyu D, Chen Rong
Abstract excerpt
Genomic sequencing studies in the past several years have yielded a large number of cancer somatic mutations. There remains a major challenge in delineating a small fraction of somatic mutations that are oncogenic drivers from a background of predominantly passenger mutations. Although computational tools have been developed to predict the functional impact of mutations, their utility is limited. In this study,...
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