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Article

Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes.

PLoS genetics - 1 Jun 2016

Zhao Boyang, Pritchard Justin R

Abstract excerpt

The identification of biologically significant variants in cancer genomes is critical to therapeutic discovery, but it is limited by the statistical power needed to discern driver from passenger. Independent biological data can be used to filter cancer exomes and increase statistical power. Large genetic databases for inherited diseases are uniquely suited to this task because they contain specific amino acid...

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Identifiers

PMID: 27304678
DOI: 10.1371/journal.pgen.1006081
PMCID: PMC4909226

Genes

ACVR1
SOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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