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Article

Investigating cytokinesis failure as a strategy in cancer therapy.

Oncotarget - 27 Dec 2016

McKenzie Callum, D'Avino Pier Paolo

Abstract excerpt

Effective therapeutics exploit common characteristics shared amongst cancers. As many cancers present chromosomal instability (CIN), one possible approach to treat these cancers could be to increase their CIN above a threshold that would affect their viability. Here, we investigated whether causing polyploidy by cytokinesis failure could represent a useful approach. We show that cytokinesis failure caused by...

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Identifiers

PMID: 27895316
DOI: 10.18632/oncotarget.13556
PMCID: PMC5349991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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