Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell Cannibalism

24 Mar 2012

Abstract excerpt

Aneuploidy is a hallmark of human cancers originating from abnormal mitoses. Many aneuploid cancer cells also have greater-than-diploid DNA content, suggesting that polyploidy is a common precursor to aneuploidy during tumor progression. Polyploid cells can originate from cell fusion, endoreplication, and cytokinesis failure. Recently we found that cell cannibalism by entosis, a form of cell engulfment involving...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Erythrocyte Function and Pathophysiology
Share to Microtubule and mitosis dynamics
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22447569
DOI: 10.1158/0008-5472.can-11-3127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of Ploidy Increase in Human Cancers: A New Role for Cell CannibalismPMID 22447569Read ↗

Human cell polyploidization: The good and the evilSemantic proximity Read ↗

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of CancerSemantic proximity Read ↗

Proliferative polyploid cells give rise to tumors via ploidy reductionSemantic proximity Read ↗

Whole-Genome Doubling as a source of cancer: how, when, where, and why?Semantic proximity Read ↗

Endoreplication: polyploidy with purposeSemantic proximity Read ↗

The Enigma of Cancer Polyploidy as Deciphered by Evolutionary Cancer Cell Biology (ECCB)Semantic proximity Read ↗

Meeting report: 1st international conference on polyploid giant cancer cells—biology, clinical applications, and the birth of a new field in cancer researchSemantic proximity Read ↗

Aneuploidy as a cancer vulnerabilitySemantic proximity Read ↗

Polyploidy, aneuploidy and the evolution of cancer.Semantic proximity Read ↗

Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.Semantic proximity Read ↗

Polyploidy: The Link Between Senescence and CancerSemantic proximity Read ↗

Unscheduled polyploidy synergizes with oncogenic mutations to enhance genome instability and tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.