Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.

doi:10.1002/cam4.959

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Article

Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.

Cancer medicine - 1 Jan 2017

Yasumoto Makiko, Sakamoto Etsuko, Ogasawara Sachiko, Isobe Taro, Kizaki Junya, Sumi Akiko, Kusano Hironori, Akiba Jun, Torimura Takuji, Akagi Yoshito, Itadani Hiraku, Kobayashi Tsutomu, Hasako Shinichi, Kumazaki Masafumi, Mizuarai Shinji, Oie Shinji, Yano Hirohisa

Abstract excerpt

The prognosis of patients with Borrmann type IV gastric cancer (Type IV) is extremely poor. Thus, there is an urgent need to elucidate the molecular mechanisms underlying the oncogenesis of Type IV and to identify new therapeutic targets. Although previous studies using whole-exome and whole-genome sequencing have elucidated genomic alterations in gastric cancer, none has focused on comprehensive genetic analysis...

Topics

Adult
Aged
Aged, 80 and over
Exome
Female
Gene Amplification
Gene Expression Regulation, Neoplastic
Genetic Association Studies
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Mutation Rate

Receptor, IGF Type 1

Receptors, Somatomedin

Sequence Analysis, DNA

Sequence Deletion

Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27891760
DOI: 10.1002/cam4.959
PMCID: PMC5269692

Genes

MRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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