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Comprehensive genome- and transcriptome-wide analyses of mutations associated with microsatellite instability in Korean gastric cancers.

Genome research - 1 Jul 2013

Yoon Kwiyeom, Lee Sunghoon, Han Tae-Su, Moon So Yeon, Yun Sun Mi, Kong Seong-Ho, Jho Sungwoong, Choe Jinny, Yu Jieun, Lee Hyuk-Joon, Park Ji Hyun, Kim Hak-Min, Lee So Yeun, Park Jongsun, Kim Woo-Ho, Bhak Jong, Yang Han-Kwang, Kim Seong-Jin

Abstract excerpt

Microsatellite instability (MSI) is a critical mechanism that drives genetic aberrations in cancer. To identify the entire MS mutation, we performed the first comprehensive genome- and transcriptome-wide analyses of mutations associated with MSI in Korean gastric cancer cell lines and primary tissues. We identified 18,377 MS mutations of five or more repeat nucleotides in coding sequences and untranslated regions...

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Frameshift Mutation
Microsatellite Instability
Republic of Korea
RNA Processing, Post-Transcriptional

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

Untranslated Regions

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PMID: 23737375
DOI: 10.1101/gr.145706.112
PMCID: PMC3698504

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