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Article

Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion.

Biochemical and biophysical research communications - 16 Apr 2010

Asaoka Yoshinari, Tada Motohisa, Ikenoue Tsuneo, Seto Motoko, Imai Mitsuho, Miyabayashi Koji, Yamamoto Keisuke, Yamamoto Shinzo, Kudo Yotaro, Mohri Dai, Isomura Yoshihiro, Ijichi Hideaki, Tateishi Keisuke, Kanai Fumihiko, Ogawa Seishi, Omata Masao, Koike Kazuhiko

Abstract excerpt

Receptor tyrosine kinases (RTKs) are involved in oncogenesis and disease progression for many cancers. Inhibitors targeting them are vigorously developed and some of them are tested in the clinical setting. Amplifications of certain RTKs (c-Met, FGFR2 and ErbB2) have been associated with human gastric cancer progression. According to our genome-wide scans of genetic lesions in 34 gastric cancer cell lines using...

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Share to Chromosomes, Human, Pair 7
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20331976
DOI: 10.1016/j.bbrc.2010.03.120

Genes

FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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