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Article

Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.

Cancer science - 1 Feb 2017

Oikawa Yu, Morita Kei-Ichi, Kayamori Kou, Tanimoto Kousuke, Sakamoto Kei, Katoh Hiroto, Ishikawa Shumpei, Inazawa Johji, Harada Hiroyuki

Abstract excerpt

This study aimed to clarify the genomic factors associated with the diagnosis and prognosis of oral squamous cell carcinoma via next-generation sequencing. We evaluated data from 220 cases of oral squamous cell carcinoma. Genomic DNA was eluted using formalin-fixed, paraffin-embedded samples, and targeted resequencing of 50 cancer-related genes was performed. In total, 311 somatic mutations were detected in 220...

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Identifiers

PMID: 27889930
DOI: 10.1111/cas.13126
PMCID: PMC5329163

Genes

AKT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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