Article
Lenalidomide enhances the function of dendritic cells generated from patients with multiple myeloma.
Experimental hematology - 1 Feb 2017
Vo Manh-Cuong, Anh-NguyenThi Truc, Lee Hyun-Ju, Nguyen-Pham Thanh-Nhan, Jaya Lakshmi Thangaraj, Jung Sung-Hoon, Kim Hyeoung-Joon, Lee Je-Jung
Abstract excerpt
Lenalidomide (LEN) has been used as an immunomodulatory drug with direct and indirect anti-tumor effects. In this study, we evaluated the effect of LEN on the differentiation, maturation, and function of dendritic cells (DCs) in patients with multiple myeloma in vitro. Various doses of LEN were added after the monocytes had differentiated into immature DCs and were activated into mature DCs. LEN (5 μg/mL) was the...
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