Article
Impaired functionality and phenotypic profile of dendritic cells from patients with multiple myeloma.
Clinical and experimental immunology - 1 Apr 2006
Brimnes M K, Svane I M, Johnsen H E
Abstract excerpt
Multiple myeloma (MM) is a B cell cancer characterized by clonal proliferation in the bone marrow and impaired immunity. Because MM is an incurable malignancy, efficient consolidation is needed urgently. Targeting clonotypic B cells by idiotype vaccination has proved the principle to be effective and indicated that future strategies, including dendritic cell-based vaccination, could be a suitable approach....
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