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Article

Conserved and novel functions of programmed cellular senescence during vertebrate development

1 Jan 2016

Abstract excerpt

Cellular senescence, a form of stable cell cycle arrest that is traditionally associated with tumour suppression, has been recently found to occur during mammalian development. Here, we show that cell senescence is an intrinsic part of the developmental programme in amphibians. Programmed senescence occurs in specific structures during defined time windows during amphibian development. It contributes to the...

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PMID: 27888193
DOI: 10.1242/dev.138222

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