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Article

Cellular Senescence in the Development and Treatment of Cancer

23 Nov 2009

Abstract excerpt

Senescence is defined as an irreversible growth arrest that is characterised by a changed morphology, gene expression pattern and chromatin structure as well as an activated DNA damage response. Senescence has a dual role for tumour development-it acts as a tumour suppressor to prevent the proliferation of seriously damaged cells. Important mechanisms ensuring the stop of genomically altered cells to proliferate...

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PMID: 20214620
DOI: 10.2174/138161210789941874

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