Senescence-like phenotype in post-mitotic cells of mice entering middle age

Abstract excerpt

Staining mice tissues for β-galactosidase activity is a fundamental tool to detect age- or disease-associated cellular senescence. However, reported analyses of positivity for senescence-associated β-galactosidase activity or for other markers of senescence in post-mitotic cells of healthy murine tissues have been fragmentary or inconclusive. Here, we attempted to independently deepen this knowledge using...

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• Share to Genetics, Aging, and Longevity in Model Organisms
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