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Article

Increased tolerance to stress in cardiac expressed gain-of-function of adenosine triphosphate-sensitive potassium channel subunit Kir6.1.

The Journal of surgical research - 1 Dec 2016

Henn Matthew C, Janjua M Burhan, Zhang Haixia, Kanter Evelyn M, Makepeace Carol M, Schuessler Richard B, Nichols Colin G, Lawton Jennifer S

Abstract excerpt

BACKGROUND: The adenosine triphosphate-sensitive potassium (KATP) channel opener diazoxide (DZX) prevents myocyte volume derangement and reduced contractility secondary to stress. KATP channels are composed of pore-forming (Kir6.1 or Kir6.2) and regulatory (sulfonylurea receptor, SUR1 or SUR2) subunits. Gain of function (GOF) of Kir6.1 subunits has been implicated in cardiac pathology in Cantu syndrome in humans...

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Identifiers

PMID: 27884343
DOI: 10.1016/j.jss.2016.08.043
PMCID: PMC6927332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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