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Article

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity

10 Dec 2019

Abstract excerpt

Cantu syndrome (CS) is a complex disorder caused by gain-of-function (GoF) mutations in ABCC9 and KCNJ8, which encode the SUR2 and Kir6.1 subunits, respectively, of vascular smooth muscle (VSM) KATP channels. CS includes dilated vasculature, marked cardiac hypertrophy, and other cardiovascular abnormalities. There is currently no targeted therapy, and it is unknown whether cardiovascular features can be reversed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31821173
DOI: 10.1172/jci130571

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