Article
Swelling-activated chloride channels in cardiac physiology and pathophysiology.
Progress in biophysics and molecular biology - 1 Jan 2000
Baumgarten Clive M, Clemo Henry F
Abstract excerpt
Characteristics and functions of the cardiac swelling-activated Cl current (I(Cl,swell)) are considered in physiologic and pathophysiologic settings. I(Cl,swell) is broadly distributed throughout the heart and is stimulated not only by osmotic and hydrostatic increases in cell volume, but also by agents that alter membrane tension and direct mechanical stretch. The current is outwardly rectifying, reverses...
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