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Article

Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.

Heart rhythm - 1 Nov 2015

Levin Mark D, Zhang Haixia, Uchida Keita, Grange Dorothy K, Singh Gautam K, Nichols Colin G

Abstract excerpt

BACKGROUND: Gain-of-function (GOF) mutations in the KATP channel subunits Kir6.1 and SUR2 cause Cantu syndrome (CS), a disease characterized by multiple cardiovascular abnormalities. OBJECTIVE: The purpose of this study was to better determine the electrophysiologic consequences of such GOF mutations in the heart. METHODS: We generated transgenic mice (Kir6.1-GOF) expressing ATP-insensitive Kir6.1[G343D] subunits...

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Source

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Identifiers

PMID: 26142302
DOI: 10.1016/j.hrthm.2015.06.042
PMCID: PMC4624040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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