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Article

Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation.

PloS one - 1 Jan 2017

Gao Mei Hua, Lai N Chin, Giamouridis Dimosthenis, Kim Young Chul, Guo Tracy, Hammond H Kirk

Abstract excerpt

OBJECTIVES: Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. We previously generated a catalytically inactive mutant of AC6 (AC6mut) that has an attenuated response to β-adrenergic receptor stimulation, and, consequently, exhibits reduced myocardial cAMP generation. In the current study...

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PMID: 28767701
DOI: 10.1371/journal.pone.0181282
PMCID: PMC5540275

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