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Article

Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.

Journal of the American Heart Association - 23 Aug 2013

Li Anlong, Knutsen Russell H, Zhang Haixia, Osei-Owusu Patrick, Moreno-Dominguez Alex, Harter Theresa M, Uchida Keita, Remedi Maria S, Dietrich Hans H, Bernal-Mizrachi Carlos, Blumer Kendall J, Mecham Robert P, Koster Joseph C, Nichols Colin G

Abstract excerpt

BACKGROUND: KATP channels, assembled from pore-forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of Kir6.2 results in hypoglycemia and hyperinsulinemia, whereas loss of Kir6.1 causes Prinzmetal angina-like symptoms in mice. Conversely, overactivity of Kir6.2 induces neonatal diabetes in mice and humans, but consequences of Kir6.1 overactivity are unknown....

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Identifiers

PMID: 23974906
DOI: 10.1161/JAHA.113.000365
PMCID: PMC3828800

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