KATP channel Kir6.2 E23K variant overrepresented in human heart failure is associated with impaired exercise stress response.

Abstract excerpt

ATP-sensitive K+ (K(ATP)) channels maintain cardiac homeostasis under stress, as revealed by murine gene knockout models of the KCNJ11-encoded Kir6.2 pore. However, the translational significance of K(ATP) channels in human cardiac physiology remains largely unknown. Here, the frequency of the minor K23 allele of the common functional Kir6.2 E23K polymorphism was found overrepresented in 115 subjects with...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Exercise Test
• Share to KCNJ11 gene
• Share to Genotype