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Article

Genetic contribution and functional impairment of inflammasome in sickle cell disease.

Cytokine - 1 Jan 2022

de Freitas Dutra Valéria, Leal Vinícius Nunes Cordeiro, Fernandes Fernanda Pereira, Souza Cláudia Regina Lustosa, Figueiredo Maria Stella, Pontillo Alessandra

Abstract excerpt

BACKGROUND: Sickle cell disease (SCD), one of the most common single-gene disorders, is caused by mutations in the hemoglobin ß-chain gene. Clinical presentation is heterogeneous, and inflammation is a common condition. Thereby, we hypothesized that inflammasome and related cytokine IL-1ß could represent significant SCD pathogenesis contributors. MATERIAL AND METHODS: 161 SCD (SS/Sβ) patients were enrolled for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34627079
DOI: 10.1016/j.cyto.2021.155717

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