Impaired progesterone production in Nr5a2+/- mice leads to a reduction in female reproductive function.

Abstract excerpt

NR5A2 is an orphan nuclear receptor involved in cholesterol metabolism and embryogenesis. The high level of expression of NR5A2 in the ovary and its involvement in the regulation of steroidogenic gene expression also suggest a role for this transcription factor in female reproductive function. In vivo evidence for a role for NR5A2 in fertility, however, is still lacking. In order to address this possibility, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Estrogens
• Share to Infertility, Female